The precise causes of pancreatic cancer have not yet been determined, but there is evidence that some risk factors may be associated with an increased probability of developing pancreatic cancer:
Age: Pancreatic cancer can strike at any age, but it occurs most often in men and women over 50 years old. Age is probably the most common risk factor.
Family History: A family history of colon cancer, pancreatic cancer, or melanoma can indicate an increased risk for pancreatic cancer.
Cigarette smoking: Current estimates suggest that about 30% of pancreatic cancer cases are due to cigarette smoking. Smokers and smokeless tobacco users have a 2-10 times greater risk of developing pancreatic cancer than non-smokers. Fortunately, long-term smoking cessation reduces risk by about 30%.
Occupational exposure: Certain chemicals used in manufacturing may be associated with an increased risk, including 2-naphthylamine, benzidine, and derivatives of gasoline. Prolonged exposure to DDT and related chemicals may also be associated with the development of pancreatic cancer in humans.
Low dietary intake of fruits and vegetables: A diet high in fruits, vegetables and fiber and low in fat may reduce your risk.
Food preparation methods: grilling or charring meats represents the highest risk for developing pancreatic cancer.
Obesity: There may be a possible link between pancreatic cancer and obesity. Researchers are working to clarify of this potential link.
Several rare hereditary syndromes are associated with an increased risk of pancreatic cancer, including:
